What Makes Tissue Microarray A Great Research Tool In Medical Science
We are living in the modern world where medical science is doing great to make our life at peace and away from diseases. Talking about the recent innovation in respect of pathology, tissue microarray emerges first at the fingertips. This is a kind of technique coming up with the method of representing small tissue samples from hundreds of different cases. These tissues are assembled onto a single histologic slide to enhance the ratio throughput analysis of multiple specimens at the same time.
Moreover, this technique also includes producing paraffin blocks extracted with the help of the cylindrical tissue cores from the different paraffin donor blocks. And after that, these are re-embedded into one single paraffin block having defined microarray coordinates.
Significance Of Tissue Microarray
The motto using tissue microarray is that it makes a researcher to simultaneously analyze the molecular targets for DNA, mRNA and another kind of protein level indicators following one single identical and standardized conditions of a glass slide. And therefore it is being used on a large scale in the medical field. Moreover, this way also plays a major role to impart the researchers having maximal preservation along with the use of archival tissue samples.
Tissue microarray also portrays a significant role in retrospective and prospective human tissue studies. The best thing is that it is one of the highly practical tools which are used for high throughput molecular analysis of the tissues. You may not know but Tissue microarray also helps for conducting an analysis of new diagnostic and prognostic markers for various other human diseases such as cancers. And we all know how cancer cases are increasing day-by-day. It has also many other potential applications in respect of basic research, prognostic oncology, and drug discovery in a great way.
The Procedure Followed For A Tissue Microarray And Its Applications
With the wide reception of the BioChain tissue microarray technique, its procedure is being followed widely. You might be curious to understand this technique and it is being explored here in a great way. To put in simple worlds, a hollow needle makes possible to remove the cores of the tissue having a size of 0.6 mm in a diameter. And then this region is placed on the paraffin block.
This paraffin block having tissue is used in respect of clinical biopsy and tumor sampling. It can be said that Tissue Microarray has brought a great change to the medical field. Now, it finds it’s better than before. This is needed to do in a very careful way. It is being mentioned here that these already prepared sections are cut following the microtome and then it can easily be used for any sorts of histological analysis. According to the studies, each microarray can easily be used into a total number of 100-500 sections.
This tool is being used on a large scale as it is quite helpful regarding predictive cancer markers and treatment as well. This technique is also significant with respect to mapping protein expression on a sophisticated scale. And it also shows that Tissue Microarray is having a great future to bring huge changes in the medical field to human life better.